Phenotypes associated with this allele

• Allele Symbol: Vgll4^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6360734
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Vgll4^tm1b(EUCOMM)Hmgu/Vgll4^tm1c(EUCOMM)Hmgu Yap1^tm1.1Fcam/Yap1^+ Tg(Tek-cre)1Ywa/0	involves: 129S4/SvJae * C57BL/6N * CBA * SJL	MGI:6360911
cn2	Vgll4^tm1b(EUCOMM)Hmgu/Vgll4^tm1c(EUCOMM)Hmgu Gt(ROSA)26Sor^tm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor^+ Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL	MGI:6360909
cn3	Vgll4^tm1b(EUCOMM)Hmgu/Vgll4^tm1c(EUCOMM)Hmgu H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * C57BL/6N * CBA/J * SJL	MGI:6360913
cn4	Vgll4^tm1b(EUCOMM)Hmgu/Vgll4^tm1c(EUCOMM)Hmgu Tg(Tek-cre)1Ywa/0	involves: C57BL/6N * CBA * SJL	MGI:6360907

Genotype
MGI:6360911

cn1

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu}; Yap1^tm1.1Fcam/Yap1⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N • hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates

Genotype
MGI:6360909

cn2

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu}; Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL

cardiovascular system

abnormal heart development ( J:273437 )

• non-cell autonomous, enhanced proliferation of endothelial-derived valvar interstitial cells leading to valve thickening

Genotype
MGI:6360913

cn3

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu}; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J * SJL

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N • neonatal and adult mice exhibit normal valves

Genotype
MGI:6360907

cn4

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu}; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6N * CBA * SJL

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N • neonatal mice exhibit normal capillary vessel distribution and endocardium

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

abnormal heart development ( J:273437 )

• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age

thick aortic valve cusps ( J:273437 )

• at P0 and in adult mice

thick pulmonary valve cusps ( J:273437 )

• at P0 and in adult mice

increased heart left ventricle weight ( J:273437 )

cardiac fibrosis ( J:273437 )

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

cellular

decreased apoptosis ( J:273437 )

• reduced apoptosis of endothelial-derived valvar interstitial cells

increased cell proliferation ( J:273437 )

• prolonged cell proliferation of endothelial-derived valvar interstitial cells

muscle

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

growth/size/body

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age