Analysis Tools
mortality/aging
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• viable at E18.5 but no viable postnatal mice are found
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nervous system
| N |
• no abnormalities in proliferation of neuronal progenitor cells is seen at E13.5 in cortical regions
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• increase in the number of TUNEL positive cells in the thalamus and developing cerebrocortical regions of the brain at E14.5
• increase in the number of apoptotic cells in the thalamus but not the cortical regions at E13.5
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• unusual dark red structures are visible in the brain at E18.5
• most dorsal parts including the cerebral cortex are lost at E18.5; however, most medioventral Tuj1 positive regions remain
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• wider at E13.5
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• abnormal shape at E13.5
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• severely reduced thickness at E14.5
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• loss of the cerebral cortex at E18.5
• abnormal shape at E13.5
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• severely reduced thickness at E14.5
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vision/eye
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• at E18.5
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cellular
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• increase in the number of TUNEL positive cells in the thalamus and developing cerebrocortical regions of the brain at E14.5
• increase in the number of apoptotic cells in the thalamus but not the cortical regions at E13.5
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