Phenotypes associated with this allele

• Allele Symbol: Pogz^tm1.2Jrk
• Allele Name: targeted mutation 1.1, Jonathan R Keller
• Allele ID: MGI:6360952
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pogz^tm1.2Jrk/Pogz^tm1.2Jrk	B6.129S1(Cg)-Pogz^tm1.2Jrk	MGI:6361000
hm2	Pogz^tm1.2Jrk/Pogz^tm1.2Jrk	involves: 129S1/Sv * C57BL/6J	MGI:6361001

Genotype
MGI:6361000

hm1

• Allelic Composition: Pogz^tm1.2Jrk/Pogz^tm1.2Jrk
• Genetic Background: B6.129S1(Cg)-Pogz^tm1.2Jrk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:271614 )

• embryos rarely survive beyond E16.5

Genotype
MGI:6361001

hm2

• Allelic Composition: Pogz^tm1.2Jrk/Pogz^tm1.2Jrk
• Genetic Background: involves: 129S1/Sv * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:271614 )

• reduced survival observed at E15.5 through E18.5

embryonic lethality during organogenesis, incomplete penetrance ( J:271614 )

• fewer than expected mice are present at E10.5

preweaning lethality, complete penetrance ( J:271614 )

• no mice are present at weaning

liver/biliary system

liver hypoplasia ( J:271614 )

• at E15.5 with reduced erythroid, B and myeloid cell numbers without a reduction in frequency

growth/size/body

decreased fetal size ( J:271614 )

• at E15.5

hematopoietic system

anemia ( J:271614 )

• at E15.5