Phenotypes associated with this allele

• Allele Symbol: Cdc37^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6361011
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc37^em1(IMPC)J/Cdc37^em1(IMPC)J	C57BL/6NJ-Cdc37^em1(IMPC)J/Mmjax	MGI:6492752
ht2	Cdc37^em1(IMPC)J/Cdc37^+	C57BL/6NJ-Cdc37^em1(IMPC)J/Mmjax	MGI:6696681

Genotype
MGI:6492752

hm1

• Allelic Composition: Cdc37^em1(IMPC)J/Cdc37^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Cdc37^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Cdc37

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cdc37^em1(IMPC)J/Cdc37^em1(IMPC)J mice exhibit embryonic lethality, with no embryos detected at E7.5 and lower number of embryos than expected at E3.5. Blastocysts grown in vitro fail to hatch from the zona pellucida.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• early blastocysts are present at E3.5 (15% versus expected 25%, n=20); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:6696681

ht2

• Allelic Composition: Cdc37^em1(IMPC)J/Cdc37⁺
• Genetic Background: C57BL/6NJ-Cdc37^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Cdc37

behavior/neurological

increased startle reflex ( J:211773 )

♂

IMPC - JAX

hyperactivity ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - JAX