Analysis Tools
homeostasis/metabolism
| N |
• whether fed regular chow or a high-fat diet, mice exhibit normal, energy expenditure, respiratory exchange ratio and tissue weights
(J:279017)
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 N |
• at 10 weeks of age, ad lib-fed males show no differences in blood glucose levels or plasma testosterone levels relative to wild-type controls
(J:314392)
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• males fed a high-fat diet for 8 weeks show significantly lower body weight gain than similarly fed wild-type controls
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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• in hyperinsulinemic-euglycemic clamp studies, mice fed regular chow or a high-fat diet exhibit increased steady-state glucose infusion rate and increased glucose disposable rate compared with wild-type mice
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• asprosin treatment fails to increase blood glucose levels at 10 or 40 weeks of age, unlike in wild-type controls
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• when fed regular chow or a high-fat diet
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• not as much as in Gcgrem1Tshu homozygotes
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• when fed regular chow and more so when fed a high-fat diet
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• whether fed regular chow or a high-fat diet
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• reduced glucose output from hepatocyte from cultured hepatocytes and in mice whether fed regular chow or a high-fat diet
• reduced asprosin-induced glucose production in hepatocytes
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• greater whole body and liver insulin sensitivity when fed regular chow or a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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liver/biliary system
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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adipose tissue
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• when fed regular chow and more so when fed a high-fat diet
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• when fed regular chow and more so when fed a high-fat diet
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growth/size/body
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N |
• 10-week-old ad lib-fed males show normal body weight relative to wild-type controls
• asprosin treatment has no effect on body weight at 10 or 40 weeks of age, similar to wild-type controls
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• when fed regular chow and more so when fed a high-fat diet
(J:279017)
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• at 12 and 16 weeks of age, males fed regular chow show significantly lower body weight than similarly fed wild-type controls
(J:314392)
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• males fed a high-fat diet for 8 weeks show significantly lower body weight gain than similarly fed wild-type controls
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behavior/neurological
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• when fed regular chow and more so when fed a high-fat diet
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reproductive system
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N |
• at 10 weeks of age, ad lib-fed males show normal testis weight, morphology and histology with no differences in sperm number, sperm viability or morphology, or frequency of copulation plugs relative to wild-type controls
• asprosin treatment has no effect on testis weight, morphology and histology, or sperm number, sperm viability and morphology at 10 or 40 weeks of age, similar to wild-type controls
• sperm number and sperm viability are normal whether mice are fed regular chow or a high-fat diet for 8 weeks
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• when mated with wild-type females, 10-week-old ad lib-fed males exhibit reduced fertilization potential relative to wild-type males
• asprosin treatment fails to significantly increase the fertilization potential of 10- or 40-week-old males, unlike in wild-type controls
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• when 10-week-old ad lib-fed males are mated with wild-type females, the % of 2-cell states is significantly lower than that for wild-type controls (50% vs 75%)
• however, the % of 2-cell states following in vitro fertilization is normal
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• 10-week-old ad lib-fed males show reduced sperm ATP content
• asprosin treatment fails to significantly increase the ATP and cAMP content in sperm from 10- or 40-week-old males, unlike in wild-type controls
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• at 10 and 40 weeks of age, ad lib-fed males exhibit severely reduced sperm progressive motility relative to age-matched wild-type controls
• asprosin treatment fails to significantly enhance progressive motility in sperm from 10- or 40-week-old males, unlike in age-matched wild-type controls
• sperm progressive motility is reduced both on regular chow and a high-fat diet
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• at 10 weeks of age, ad lib-fed males show a dramatic increase in the % of sperm with slow motility
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cellular
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• at 10 and 40 weeks of age, ad lib-fed males exhibit severely reduced sperm progressive motility relative to age-matched wild-type controls
• asprosin treatment fails to significantly enhance progressive motility in sperm from 10- or 40-week-old males, unlike in age-matched wild-type controls
• sperm progressive motility is reduced both on regular chow and a high-fat diet
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• at 10 weeks of age, ad lib-fed males show a dramatic increase in the % of sperm with slow motility
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