All Phenotypes Nus1<tm1.2Qrm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nus1^tm1.2Qrm
targeted mutation 1.2, Qing Robert Miao
MGI:6361026

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nus1^tm1.2Qrm/Nus1^tm1.2Qrm	involves: 129P2/OlaHsd * FVB/N	MGI:6361027
ht2	Nus1^tm1.2Qrm/Nus1⁺	involves: 129P2/OlaHsd * FVB/N	MGI:6361028

Allelic Composition	Nus1^tm1.2Qrm/Nus1^tm1.2Qrm
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:229464 )

• early embryonic lethality with no embryos seen at E7.5

Allelic Composition	Nus1^tm1.2Qrm/Nus1⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular development ( J:229464 )

• embryoid bodies derived from embryonic stem cells exhibit defective blood vessel development, form dilated and truncated EC tubes which have less branching and fail to develop into a tree-like structure in vitro

• however, heterozygous mice are viable

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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