All Phenotypes Nus1<tm1.2Qrm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nus1^tm1.2Qrm
targeted mutation 1.2, Qing Robert Miao
MGI:6361026

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nus1^tm1.2Qrm/Nus1^tm1.2Qrm	involves: 129P2/OlaHsd * FVB/N	MGI:6361027
ht2	Nus1^tm1.2Qrm/Nus1⁺	involves: 129P2/OlaHsd * FVB/N	MGI:6361028

Allelic Composition	Nus1^tm1.2Qrm/Nus1^tm1.2Qrm
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:229464 )

• early embryonic lethality with no embryos seen at E7.5

Allelic Composition	Nus1^tm1.2Qrm/Nus1⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular development ( J:229464 )

• embryoid bodies derived from embryonic stem cells exhibit defective blood vessel development, form dilated and truncated EC tubes which have less branching and fail to develop into a tree-like structure in vitro

• however, heterozygous mice are viable

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24