Phenotypes associated with this allele

• Allele Symbol: Mir216b^em1Uf
• Allele Name: endonuclease-mediated mutation 1, University of Florida
• Allele ID: MGI:6361477
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir216b^em1Uf/Mir216b^em1Uf	C57BL/6-Mir216b^em1Uf	MGI:6361644
cx2	Mir216b^em1Uf/Mir216b^em1Uf Tg(Ela-KRAS*G12D)9Eps/0	involves: C57BL/6N * FVB	MGI:6361642

Genotype
MGI:6361644

hm1

• Allelic Composition: Mir216b^em1Uf/Mir216b^em1Uf
• Genetic Background: C57BL/6-Mir216b^em1Uf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreatic acinar-to-ductal metaplasia ( J:278847 )

• in ductal cells cultured on collagen in the absence of growth factors

increased susceptibility to induced pancreatitis ( J:278847 )

• acute following intraperitoneal injections of caerulein

• however, pancreata completely regenerates by day 7

immune system

increased susceptibility to induced pancreatitis ( J:278847 )

• acute following intraperitoneal injections of caerulein

• however, pancreata completely regenerates by day 7

Genotype
MGI:6361642

cx2

• Allelic Composition: Mir216b^em1Uf/Mir216b^em1Uf; Tg(Ela-KRAS*G12D)9Eps/0
• Genetic Background: involves: C57BL/6N * FVB

neoplasm

increased pancreas tumor incidence ( J:278847 )

• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands

increased pancreas tumor incidence ( J:278847 )

• as in Tg(Ela-KRAS*G12D)9Eps mice