Phenotypes associated with this allele

• Allele Symbol: Mir217^em2Uf
• Allele Name: endonuclease-mediated mutation 2, University of Florida
• Allele ID: MGI:6361485
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir217^em2Uf/Mir217^em2Uf	C57BL/6-Mir217^em2Uf	MGI:6361638
cx2	Mir217^em2Uf/Mir217^em2Uf Tg(Ela-KRAS*G12D)9Eps/0	involves: C57BL/6N * FVB	MGI:6361636

Genotype
MGI:6361638

hm1

• Allelic Composition: Mir217^em2Uf/Mir217^em2Uf
• Genetic Background: C57BL/6-Mir217^em2Uf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreatic acinar-to-ductal metaplasia ( J:278847 )

• in ductal cells cultured on collagen in the absence of growth factors

increased susceptibility to induced pancreatitis ( J:278847 )

• acute following intraperitoneal injections of caerulein

• however, pancreata completely regenerates by day 7

immune system

increased susceptibility to induced pancreatitis ( J:278847 )

• acute following intraperitoneal injections of caerulein

• however, pancreata completely regenerates by day 7

Genotype
MGI:6361636

cx2

• Allelic Composition: Mir217^em2Uf/Mir217^em2Uf; Tg(Ela-KRAS*G12D)9Eps/0
• Genetic Background: involves: C57BL/6N * FVB

neoplasm

increased pancreas tumor incidence ( J:278847 )

• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands

increased pancreas tumor incidence ( J:278847 )

• as in Tg(Ela-KRAS*G12D)9Eps mice