Phenotypes associated with this allele

• Allele Symbol: Rps23rg1^em1Ywuz
• Allele Name: endonuclease-mediated mutation 1, Yun-wu Zhang
• Allele ID: MGI:6361943
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rps23rg1^em1Ywuz/Rps23rg1^em1Ywuz	C57BL/6-Rps23rg1^em1Ywuz	MGI:6362606

Genotype
MGI:6362606

hm1

• Allelic Composition: Rps23rg1^em1Ywuz/Rps23rg1^em1Ywuz
• Genetic Background: C57BL/6-Rps23rg1^em1Ywuz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:272361 )

• reduced spontaneous alternation in a modified T-maze test

• however, combined expression of PSD-93 and PSD-95 rescues the phenotype

impaired contextual conditioning behavior ( J:272361 )

• reduced freezing

impaired cued conditioning behavior ( J:272361 )

• reduced freezing

impaired spatial learning ( J:272361 )

• reduced escape latency declination in a Morris water maze

abnormal response to novel object ( J:272361 )

• during testing, mice fail to exhibit preference for exploring a novel object over a familiar one compared with wild-type mice

decreased locomotor activity ( J:272361 )

• slightly in an open field without a preference for the central areas

nervous system

abnormal postsynaptic density morphology ( J:272361 )

• reduction in presynaptic marker expression, length and width

decreased excitatory postsynaptic current amplitude ( J:272361 )

• reduced amplitude of AMPA and NMDA receptor-mediated evoked EPSC in CA1 pyramidal cells

abnormal excitatory postsynaptic potential ( J:272361 )

• reduced field excitatory postsynaptic potential slopes

reduced long-term potentiation ( J:272361 )

• however, combined expression of PSD-93 and PSD-95 rescues the phenotype

abnormal miniature excitatory postsynaptic currents ( J:272361 )

• reduced amplitude of AMPA and NMDA receptor-mediated mEPSC in CA1 pyramidal cells

• reduced frequencies of AMPA and NMDA receptor-mediated mEPSC in neurons