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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epsti1em1Mjnh
endonuclease-mediated mutation 1, Myong-Joon Hahn
MGI:6362648
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epsti1em1Mjnh/Epsti1em1Mjnh Not Specified MGI:6362655


Genotype
MGI:6362655
hm1
Allelic
Composition		 Epsti1em1Mjnh/Epsti1em1Mjnh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epsti1em1Mjnh mutation (0 available); any Epsti1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage differentiation ( J:272013 )
• M2 macrophage differentiation is enhanced while M1 polarization is inhibited compared to in wild-type mice
decreased macrophage cell number ( J:272013 )
• M1 macrophages in the peritoneal cavity

cellular
abnormal macrophage differentiation ( J:272013 )
• M2 macrophage differentiation is enhanced while M1 polarization is inhibited compared to in wild-type mice

hematopoietic system
abnormal macrophage differentiation ( J:272013 )
• M2 macrophage differentiation is enhanced while M1 polarization is inhibited compared to in wild-type mice
decreased macrophage cell number ( J:272013 )
• M1 macrophages in the peritoneal cavity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory