Phenotypes associated with this allele

• Allele Symbol: Noc4l^tm1.1Nju
• Allele Name: targeted mutation 1.1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6362739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Noc4l^tm1.1Nju/Noc4l^tm1.1Nju	involves: C57BL/6 * FVB/N	MGI:6362742

Genotype
MGI:6362742

hm1

• Allelic Composition: Noc4l^tm1.1Nju/Noc4l^tm1.1Nju
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:247476 )

• no homozygotes are recovered at E8.5 to E16.5, however mutants are present at the 2-cell stage and E4.5, indicating lethality between E4.5 and E8.5

• 2-cell stage embryos grown in culture are able to compact at the 8- to 16-cell stages to form the morula but they cease to develop further into blastocysts

embryo

increased embryonic tissue cell apoptosis ( J:247476 )

• morula embryos exhibit increased apoptosis, showing increased activated caspase-3, chromatin fragmentation, and decreased number of nuclei

cellular

increased embryonic tissue cell apoptosis ( J:247476 )

• morula embryos exhibit increased apoptosis, showing increased activated caspase-3, chromatin fragmentation, and decreased number of nuclei