Phenotypes associated with this allele

• Allele Symbol: Gtpbp4^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6362818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gtpbp4^em1(IMPC)Tcp/Gtpbp4^em1(IMPC)Tcp	C57BL/6NCrl-Gtpbp4^em1(IMPC)Tcp/Cmmr	MGI:6492870
ht2	Gtpbp4^em1(IMPC)Tcp/Gtpbp4^+	C57BL/6NCrl-Gtpbp4^em1(IMPC)Tcp/Cmmr	MGI:6492869

Genotype
MGI:6492870

hm1

• Allelic Composition: Gtpbp4^em1(IMPC)Tcp/Gtpbp4^em1(IMPC)Tcp
• Genetic Background: C57BL/6NCrl-Gtpbp4^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Gtpbp4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gtpbp4^em1(IMPC)Tcp/Gtpbp4^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although early blastocysts are recovered at E3.5, no homozygous embryos are found at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:6492869

ht2

• Allelic Composition: Gtpbp4^em1(IMPC)Tcp/Gtpbp4⁺
• Genetic Background: C57BL/6NCrl-Gtpbp4^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Gtpbp4

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - TCP

decreased mean corpuscular volume ( J:211773 )

♀

IMPC - TCP

integument

abnormal coat/hair pigmentation ( J:211773 )

♂

IMPC - TCP

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♂

IMPC - TCP