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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim58tm2313.1Arte
targeted mutation 2313.1, TaconicArtemis
MGI:6362941
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trim58tm2313.1Arte/Trim58tm2313.1Arte
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:6363314


Genotype
MGI:6363314
cn1
Allelic
Composition		 Trim58tm2313.1Arte/Trim58tm2313.1Arte
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Trim58tm2313.1Arte mutation (0 available); any Trim58 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:279270 )
• mice show increased susceptibility to DSS-induced colitis, showing increased weight loss, decrease in colon length, rapid mucosal damage with greater ulcer formations and frequent transmural inflammatory cell infiltrates consisting mostly of CD11b+ myeloid cells
• however, colons show comparable improvement with signs of intestinal epithelial cell regeneration and tissue repair as in wild-type mice

immune system
increased susceptibility to induced colitis ( J:279270 )
• mice show increased susceptibility to DSS-induced colitis, showing increased weight loss, decrease in colon length, rapid mucosal damage with greater ulcer formations and frequent transmural inflammatory cell infiltrates consisting mostly of CD11b+ myeloid cells
• however, colons show comparable improvement with signs of intestinal epithelial cell regeneration and tissue repair as in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory