Phenotypes associated with this allele

• Allele Symbol: Trim58^tm2313.2Arte
• Allele Name: targeted mutation 2313.2, TaconicArtemis
• Allele ID: MGI:6362942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim58^tm2313.2Arte/Trim58^tm2313.2Arte	involves: BALB/cJ * C57BL/6N	MGI:6363315

Genotype
MGI:6363315

hm1

• Allelic Composition: Trim58^tm2313.2Arte/Trim58^tm2313.2Arte
• Genetic Background: involves: BALB/cJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:279270 )

N • mice are fertile and born at normal Mendelian ratios, exhibit no overt phenotype even after 12 months, and organs do not show any major abnormalities macroscopically

digestive/alimentary system

increased susceptibility to induced colitis ( J:279270 )

• mice treated with DSS to induce colitis show delayed intestinal mucosal healing compared to wild-type mice

• DSS-treated mice develop comparable colonic inflammation as treated wild-type mice but colitis persists and this sustained intestinal inflammation is characterized by extensive ulcerations with edematous wall thickening and transmural inflammatory infiltrates consisting mostly of CD11b+ myeloid cells, which is not seen in wild-type colons

immune system

increased susceptibility to induced colitis ( J:279270 )

• mice treated with DSS to induce colitis show delayed intestinal mucosal healing compared to wild-type mice

• DSS-treated mice develop comparable colonic inflammation as treated wild-type mice but colitis persists and this sustained intestinal inflammation is characterized by extensive ulcerations with edematous wall thickening and transmural inflammatory infiltrates consisting mostly of CD11b+ myeloid cells, which is not seen in wild-type colons