Phenotypes associated with this allele

• Allele Symbol: Atp6v1f^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6362956
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp6v1f^em1(IMPC)J/Atp6v1f^em1(IMPC)J	C57BL/6NJ-Atp6v1f^em1(IMPC)J/Mmjax	MGI:6731253

Genotype
MGI:6731253

hm1

• Allelic Composition: Atp6v1f^em1(IMPC)J/Atp6v1f^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Atp6v1f^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Atp6v1f

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atp6v1f^em1(IMPC)J/Atp6v1f^em1(IMPC)J embryos exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although early blastocysts are present in nearly normal Mendelian ratios at E3.5 (20% versus expected 25%, n=25), no homozygous embryos are recovered at E7.5; however, excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture