About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plekho2em1Lzhn
endonuclease-mediated mutation 1, Luo Zhang
MGI:6363012
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plekho2em1Lzhn/Plekho2em1Lzhn C57BL/6-Plekho2em1Lzhn MGI:6363017


Genotype
MGI:6363017
hm1
Allelic
Composition		 Plekho2em1Lzhn/Plekho2em1Lzhn
Genetic
Background		 C57BL/6-Plekho2em1Lzhn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekho2em1Lzhn mutation (0 available); any Plekho2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:270531 )
N
• macrophage exhibit normal differentiation and proliferation with normal LPS-induced macrophage activation
increased macrophage apoptosis ( J:270531 )
• of bone marrow-derived macrophage in the absence of M-CSF
decreased macrophage cell number ( J:270531 )
• F4/80highCD11b+ macrophages in the spleen, blood and peritoneal cavity
• however, mice exhibit normal bone marrow-derived macrophages

cellular
increased macrophage apoptosis ( J:270531 )
• of bone marrow-derived macrophage in the absence of M-CSF

hematopoietic system
increased macrophage apoptosis ( J:270531 )
• of bone marrow-derived macrophage in the absence of M-CSF
decreased macrophage cell number ( J:270531 )
• F4/80highCD11b+ macrophages in the spleen, blood and peritoneal cavity
• however, mice exhibit normal bone marrow-derived macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory