Phenotypes associated with this allele

• Allele Symbol: Rr250^em1Ebres
• Allele Name: endonuclease-mediated mutation 1, Emery H Bresnick
• Allele ID: MGI:6363029
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr250^em1Ebres/Rr250^em1Ebres	C57BL/6N-Rr250^em1Ebres	MGI:6363066

Genotype
MGI:6363066

hm1

• Allelic Composition: Rr250^em1Ebres/Rr250^em1Ebres
• Genetic Background: C57BL/6N-Rr250^em1Ebres

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:270526 )

• all mice die following treatment with PTZ to induce anemia unlike wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:270526 )

N • mice exhibit normal red and white blood cell counts, hemoglobin levels, platelet numbers and myelo-erythroid progenitors (bone marrow LSK, CMP, GMP, or MEP populations)

impaired hematopoiesis ( J:270526 )

• following treatment with PTZ, mice exhibit increased mortality with decreased spleen weight, hematocrit and red blood cells compared with wild-type mice

decreased erythroid progenitor cell number ( J:270526 )

• 2.9-fold fewer BFU-E from splenocytes of mice treated with PTZ

decreased erythrocyte cell number ( J:270526 )

• following treatment with PTZ

decreased hematocrit ( J:270526 )

• following treatment with PTZ

decreased hematopoietic stem cell number ( J:270526 )

• reduced CD71+Ter119-Kit+ splenic cells in PTZ-treated mice due to increased apoptosis

abnormal hematopoietic stem cell physiology ( J:270526 )

• increased apoptosis in PTZ-treated mice

liver/biliary system

decreased liver weight ( J:270526 )

• following treatment with PTZ

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:270526 )

• all mice die following treatment with PTZ to induce anemia unlike wild-type mice

increased physiological sensitivity to xenobiotic ( J:270526 )

• following treatment with PTZ, mice exhibit increased mortality with decreased spleen weight, hematocrit and red blood cells compared with wild-type mice