All Phenotypes Usp11<tm1Tac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp11^tm1Tac/Usp11^tm1Tac	involves: 129 * C57BL/6	MGI:6363165
cx2	Tg(TRAMP)8247Ng/0 Usp11^tm1Tac/Y	involves: 129 * C57BL/6	MGI:6363166
ot3	Usp11^tm1Tac/Y	involves: 129 * C57BL/6	MGI:6363164

Allelic Composition	Usp11^tm1Tac/Usp11^tm1Tac
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp11^tm1Tac mutation (0 available); any Usp11 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:270214 )

• viable

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

increased metastatic potential ( J:270214 )

• at 20 weeks of age tumor masses show severe malignant progression unlike in age-matched transgenic mice wild-type for Usp11

• prostatic tumor nodules metastasize to lymph nodes at a higher rate compared to age-matched transgenic mice wild-type for Usp11

increased tumor growth/size ( J:270214 )

• tumor masses are larger at 20 weeks of age compared to transgenic mice wild-type for Usp11

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

reproductive system

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

Allelic Composition	Usp11^tm1Tac/Y
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp11^tm1Tac mutation (0 available); any Usp11 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal fibroblast physiology ( J:270214 )

• in a wounding assay primary MEFs show more rapid wound closure compared to wild-type controls

• increase in the rates of glucose uptake, lactate production, and glutamine consumption in primary MEFs compared to wild-type controls

increased fibroblast proliferation ( J:270214 )

• primary MEFs show a higher rate of growth compared to wild-type controls

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:270214 )

• at 11 weeks of age

enlarged prostate gland ( J:270214 )

• enlarged lobes at 11 weeks of age

reproductive system

prostate gland epithelial hyperplasia ( J:270214 )

• at 11 weeks of age

enlarged prostate gland ( J:270214 )

• enlarged lobes at 11 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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