Analysis Tools
behavior/neurological
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• the ability of cocaine to increase the locomotor response is reduced in mice, indicating decreased response to cocaine
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• mice exhibit increased motivation for reward, with mice tending to press the lever for reward more frequently during the instrumental learning phase and reaching a higher breakpoint than control in a progressive ratio task
• however, mice exhibit no differences in behavior in the open field, rotarod, elevated plus maze, light-dark box, marble-burying, tail suspension and sucrose preference tests
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nervous system
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• medium spiny neurons show increased cell capacitance without alterations in membrane resistance, indicating that these neurons have a larger surface area
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• medium spiny neurons show increased dendritic arborization, with increased number of dendritic segments but normal dendritic length
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• striatal neurons show decreased neuronal excitability
• medium spiny neurons show increased cell capacitance and an increase in resting membrane potential but similar rheobase
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