All Phenotypes Septin12<tm3Plk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Septin12^tm3Plk/Septin12^tm3Plk	involves: 129 * C57BL/6	MGI:6887459
ht2	Septin12^tm3Plk/Septin12⁺	involves: 129 * C57BL/6	MGI:6887458

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:223228 )

N	• homozygotes exhibit a normal testis weight-to-body weight ratio and no significant change in the number of spermatozoa isolated from the vas deferens relative to wild-type males • % of sperm heads defects is not significantly higher than that in wild-type controls

abnormal sperm flagellum morphology ( J:223228 )

• sperm tails are rarely normal, exhibiting either a defective annulus or a bent tail

abnormal sperm annulus morphology ( J:223228 )

• ~50% of sperm exhibit a disorganized sperm annulus with disruption of the SEPT ring structure

• immunofluorescence staining of SEPT12, SEPT7, SEPT6 and SEPT2 revealed absence of all 4 septins at the annulus

kinked sperm flagellum ( J:223228 )

• 50-60% of sperm exhibit a bent tail

asthenozoospermia ( J:223228 )

• homozygotes show a more severe reduction in sperm motility than heterozygous males

cellular

abnormal sperm flagellum morphology ( J:223228 )

• sperm tails are rarely normal, exhibiting either a defective annulus or a bent tail

abnormal sperm annulus morphology ( J:223228 )

• ~50% of sperm exhibit a disorganized sperm annulus with disruption of the SEPT ring structure

• immunofluorescence staining of SEPT12, SEPT7, SEPT6 and SEPT2 revealed absence of all 4 septins at the annulus

kinked sperm flagellum ( J:223228 )

• 50-60% of sperm exhibit a bent tail

asthenozoospermia ( J:223228 )

• homozygotes show a more severe reduction in sperm motility than heterozygous males

Allelic Composition	Septin12^tm3Plk/Septin12⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12^tm3Plk mutation (0 available); any Septin12 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:223228 )

N	• heterozygotes exhibit a normal testis weight-to-body weight ratio and no significant change in the number of spermatozoa isolated from the vas deferens relative to wild-type males • no obvious morphological sperm defects are observed in the head, annulus or tail structures

asthenozoospermia ( J:223228 )

• heterozygotes show significantly reduced sperm motility relative to wild-type males

cellular

asthenozoospermia ( J:223228 )

• heterozygotes show significantly reduced sperm motility relative to wild-type males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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