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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin12tm3Plk
targeted mutation 3, Pao-Lin Kuo
MGI:6363499
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Septin12tm3Plk/Septin12tm3Plk involves: 129 * C57BL/6 MGI:6887459
ht2
 		Septin12tm3Plk/Septin12+ involves: 129 * C57BL/6 MGI:6887458


Genotype
MGI:6887459
hm1
Allelic
Composition		 Septin12tm3Plk/Septin12tm3Plk
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm3Plk mutation (0 available); any Septin12 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:223228 )
N
• homozygotes exhibit a normal testis weight-to-body weight ratio and no significant change in the number of spermatozoa isolated from the vas deferens relative to wild-type males
• % of sperm heads defects is not significantly higher than that in wild-type controls
abnormal sperm flagellum morphology ( J:223228 )
• sperm tails are rarely normal, exhibiting either a defective annulus or a bent tail
abnormal sperm annulus morphology ( J:223228 )
• ~50% of sperm exhibit a disorganized sperm annulus with disruption of the SEPT ring structure
• immunofluorescence staining of SEPT12, SEPT7, SEPT6 and SEPT2 revealed absence of all 4 septins at the annulus
kinked sperm flagellum ( J:223228 )
• 50-60% of sperm exhibit a bent tail
asthenozoospermia ( J:223228 )
• homozygotes show a more severe reduction in sperm motility than heterozygous males

cellular
abnormal sperm flagellum morphology ( J:223228 )
• sperm tails are rarely normal, exhibiting either a defective annulus or a bent tail
abnormal sperm annulus morphology ( J:223228 )
• ~50% of sperm exhibit a disorganized sperm annulus with disruption of the SEPT ring structure
• immunofluorescence staining of SEPT12, SEPT7, SEPT6 and SEPT2 revealed absence of all 4 septins at the annulus
kinked sperm flagellum ( J:223228 )
• 50-60% of sperm exhibit a bent tail
asthenozoospermia ( J:223228 )
• homozygotes show a more severe reduction in sperm motility than heterozygous males




Genotype
MGI:6887458
ht2
Allelic
Composition		 Septin12tm3Plk/Septin12+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm3Plk mutation (0 available); any Septin12 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:223228 )
N
• heterozygotes exhibit a normal testis weight-to-body weight ratio and no significant change in the number of spermatozoa isolated from the vas deferens relative to wild-type males
• no obvious morphological sperm defects are observed in the head, annulus or tail structures
asthenozoospermia ( J:223228 )
• heterozygotes show significantly reduced sperm motility relative to wild-type males

cellular
asthenozoospermia ( J:223228 )
• heterozygotes show significantly reduced sperm motility relative to wild-type males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory