behavior/neurological
N |
• mice exhibit normal general exploratory behavior
|
• increased amphetamine-induced locomotor activity during the first ten minutes of habituation
|
• reduced nest building scores at 5 h but not 24 h indicating autism-like behavior
• however, mice exhibit normal performance in a sucrose preference test
|
• reduced immobility in a tail suspension or forced swim test
|
• reduced exploration of open arms and higher latency to enter open arms in an elevated plus maze
• however, a trend toward increased novelty-induced hypophagia is not significant
|
• reduced exploration of and increased distance from a novel object
• however, mice exhibit normal novel object recognition
|
• mice spend less time investigating a novel social partner and novel social odors compared with wild-type mice
• however, mice exhibit a normal preference for a novel social partner
|
• after object presentation
|
• higher latency to fall on a rotarod only on the first day of testing
|
• only on the first day of testing
|
• mice spend less time investigating and preference for a social partner compared with wild-type mice
|
nervous system
N |
• mice exhibit normal neocortex, corpus callosum-alveus, external capsule, CA1 subregions stratum oriens, stratum pyramidale, stratum radiatum, and stratum lacunosum thickness
• mice exhibit statistically normal neurotransmitter levels in the brain
|
• of granule cells in the dentate gyrus with no change in proliferation
|
• increased immature neuronal cells
|
• thin stratum granulosum and the stratum moleculare
|
• reduced volume of prefrontal cortex
• however, mice exhibit normal striatum and hippocampus volume
|
• reduced density
• however, Purkinje cell layer is of normal thickness
|
cellular
• of granule cells in the dentate gyrus with no change in proliferation
|
• increased immature neuronal cells
|
taste/olfaction
N |
• mice exhibit normal discrimination of nonsocial odors
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autism spectrum disorder | DOID:0060041 | J:279537 |