Phenotypes associated with this allele

• Allele Symbol: Pianp^em1Bet
• Allele Name: endonuclease-mediated mutation 1, Bernhard Bettler
• Allele ID: MGI:6363553
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pianp^em1Bet/Pianp^em1Bet	involves: C57BL/6	MGI:6364112
hm2	Pianp^em1Bet/Pianp^em1Bet	Not Specified	MGI:6364111

Genotype
MGI:6364112

hm1

• Allelic Composition: Pianp^em1Bet/Pianp^em1Bet
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:276486 )

N • normal response to baclofen-induced reduction of evoked EPSC amplitude

Genotype
MGI:6364111

hm2

• Allelic Composition: Pianp^em1Bet/Pianp^em1Bet
• Genetic Background: Not Specified

nervous system

abnormal excitatory postsynaptic currents ( J:279537 )

• reduced mEPSC frequency inhibition in baclofen-treated mice

• however, baseline mEPSC frequency and amplitude are normal

decreased prepulse inhibition ( J:279537 )

• only at the prepulse levels 76 dB and 80 dB

abnormal paired-pulse facilitation ( J:279537 )

• baclofen-treated mice fail to exhibit an increase in paired-pulse ratio unlike wild-type mice

homeostasis/metabolism

abnormal glutamic acid level ( J:279537 )

• reduced baclofen-mediated inhibition of glutamate release with 40 Hz train stimulation