About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smarce1em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6363556
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smarce1em1(IMPC)J/Smarce1em1(IMPC)J C57BL/6NJ-Smarce1em1(IMPC)J/Mmjax MGI:7551223
ht2
 		Smarce1em1(IMPC)J/Smarce1+ C57BL/6NJ-Smarce1em1(IMPC)J/Mmjax MGI:7415079


Genotype
MGI:7551223
hm1
Allelic
Composition		 Smarce1em1(IMPC)J/Smarce1em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Smarce1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarce1em1(IMPC)J mutation (2 available); any Smarce1 mutation (28 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Smarce1em1(IMPC)J/Smarce1em1(IMPC)J mice exhibit embryonic lethality, with fewer than the expected number of embryos at E3.5 and E7.5, and none at E9.5. Embryos at E3.5 appear as blastocysts which hatch from the zona pellucida and form outgrowths in culture. The scarce E7.5 embryos that are recovered appear as Reichert's membrane only.

embryo
abnormal embryo morphology ( J:279207 )
• scarce homozygous embryos recovered at E7.5 appear as Reicherts membrane only

mortality/aging
embryonic lethality before implantation, incomplete penetrance ( J:279207 )
• blastocysts are recovered at lower than expected ratios at E3.5 (15% versus 25%, n=46) but both male and female embryos are present
• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• only 3 homozygous embryos (out of 56) are recovered at E7.5 but appear as Reicherts membrane only; no embryos are identified at E9.5




Genotype
MGI:7415079
ht2
Allelic
Composition		 Smarce1em1(IMPC)J/Smarce1+
Genetic
Background		 C57BL/6NJ-Smarce1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarce1em1(IMPC)J mutation (2 available); any Smarce1 mutation (28 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory