Phenotypes associated with this allele

• Allele Symbol: Phldb2^tm1Msat
• Allele Name: targeted mutation 1, Makoto Sato
• Allele ID: MGI:6364613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alpl^tm1(cre)Nagy/Alpl^+ Phldb2^tm1Msat/Phldb2^tm1Msat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JSlc * C57BL/6NCrlj * CBA/JNCrlj	MGI:6364813

Genotype
MGI:6364813

cn1

• Allelic Composition: Alpl^tm1(cre)Nagy/Alpl⁺; Phldb2^tm1Msat/Phldb2^tm1Msat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JSlc * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:275597 )

• eccentrically shifted PSD-95 localization toward the dendritic shaft

• reduced NMDA and GluA2 receptor accumulation in dendritic spines

• however, postpynaptic density areas are normal

reduced long-term potentiation ( J:275597 )

• induced by high-frequency stimulation

• however, basal synaptic function is normal

behavior/neurological

behavior/neurological phenotype ( J:275597 )

N • mice exhibit normal locomotor activity and movement in the home cage

abnormal spatial reference memory ( J:275597 )

• in a T-maze, mice exhibit fewer correct choices compared with wild-type mice

• however, duration time and total distances are normal