Phenotypes associated with this allele

• Allele Symbol: Sdc2^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6364846
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sdc2^tm1c(KOMP)Wtsi/Sdc2^tm1c(KOMP)Wtsi Tg(Cdh5-cre/ERT2)1Rha/0	involves: C57BL/6J * C57BL/6N	MGI:6364849
cn2	Sdc2^tm1c(KOMP)Wtsi/Sdc2^tm1c(KOMP)Wtsi Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: C57BL/6J * C57BL/6N * CBA	MGI:6364848

Genotype
MGI:6364849

cn1

• Allelic Composition: Sdc2^{tm1c(KOMP)Wtsi}/Sdc2^{tm1c(KOMP)Wtsi}; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:276769 )

• induced by VEGFA165 in retinal from tamoxifen-treated mice in a cornea pocket assay model

• however, response to FGF2 is normal

homeostasis/metabolism

decreased susceptibility to injury ( J:276769 )

• reduced blood flow after common femoral artery ligation with reduced perfused arterial vessels and vessel size in tamoxifen-treated mice

Genotype
MGI:6364848

cn2

• Allelic Composition: Sdc2^{tm1c(KOMP)Wtsi}/Sdc2^{tm1c(KOMP)Wtsi}; Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA

cardiovascular system

abnormal retina vasculature morphology ( J:276769 )

• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice

decreased angiogenesis ( J:276769 )

• however, vessel pruning is normal

• reduced in the retina of tamoxifen-treated mice with reduced number of tip cells

decreased vascular endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice

vision/eye

abnormal retina vasculature morphology ( J:276769 )

• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice

cellular

decreased vascular endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice

decreased endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice