About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gata6osem1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:6364852
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gata6osem1Zfa/Gata6osem1Zfa C57BL/6-1010001N08Rikem1Zfa MGI:6367568
cn2
Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:6367570
cn3
Gata6osem1Zfa/Gata6osem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 MGI:6367565
cx4
Gata6osem1Zfa/Gata6osem1Zfa
ApcMin/Apc+
involves: C57BL/6J MGI:6367566


Genotype
MGI:6367568
hm1
Allelic
Composition
Gata6osem1Zfa/Gata6osem1Zfa
Genetic
Background
C57BL/6-1010001N08Rikem1Zfa
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• induced by azoxymethane/dextran sodium sulfate

homeostasis/metabolism
• induced by azoxymethane/dextran sodium sulfate




Genotype
MGI:6367570
cn2
Allelic
Composition
Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• impaired intestinal epithelial renewal in tamoxifen treated mice




Genotype
MGI:6367565
cn3
Allelic
Composition
Gata6osem1Zfa/Gata6osem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• reduced intestinal stem cells with impaired organoid formation capacity
• however, overexpression of Ehf rescues this phenotype
• short with fewer cells than in wild-type mice
• short with fewer cells than in wild-type mice
• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice

endocrine/exocrine glands
• short with fewer cells than in wild-type mice

homeostasis/metabolism
• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice




Genotype
MGI:6367566
cx4
Allelic
Composition
Gata6osem1Zfa/Gata6osem1Zfa
ApcMin/Apc+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with ApcMin heterozygotes

neoplasm
• fewer adenoma and increased survival compared with ApcMin heterozygotes

digestive/alimentary system
• fewer adenoma and increased survival compared with ApcMin heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory