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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata6osem1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:6364852
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata6osem1Zfa/Gata6osem1Zfa C57BL/6-1010001N08Rikem1Zfa MGI:6367568
cn2
 		Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:6367570
cn3
 		Gata6osem1Zfa/Gata6osem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6367565
cx4
 		Gata6osem1Zfa/Gata6osem1Zfa
ApcMin/Apc+ 		involves: C57BL/6J MGI:6367566


Genotype
MGI:6367568
hm1
Allelic
Composition		 Gata6osem1Zfa/Gata6osem1Zfa
Genetic
Background		 C57BL/6-1010001N08Rikem1Zfa
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:268724 )
• induced by azoxymethane/dextran sodium sulfate

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:268724 )
• induced by azoxymethane/dextran sodium sulfate




Genotype
MGI:6367570
cn2
Allelic
Composition		 Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (992 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte physiology ( J:268724 )
• impaired intestinal epithelial renewal in tamoxifen treated mice




Genotype
MGI:6367565
cn3
Allelic
Composition		 Gata6osem1Zfa/Gata6osem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:268724 )
• reduced intestinal stem cells with impaired organoid formation capacity
• however, overexpression of Ehf rescues this phenotype
abnormal crypts of Lieberkuhn morphology ( J:268724 )
• short with fewer cells than in wild-type mice
abnormal small intestinal villus morphology ( J:268724 )
• short with fewer cells than in wild-type mice
abnormal enterocyte physiology ( J:268724 )
• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:268724 )
• short with fewer cells than in wild-type mice

homeostasis/metabolism
abnormal response to radiation ( J:268724 )
• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice




Genotype
MGI:6367566
cx4
Allelic
Composition		 Gata6osem1Zfa/Gata6osem1Zfa
ApcMin/Apc+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:268724 )
• compared with ApcMin heterozygotes

neoplasm
decreased intestinal adenoma incidence ( J:268724 )
• fewer adenoma and increased survival compared with ApcMin heterozygotes

digestive/alimentary system
decreased intestinal adenoma incidence ( J:268724 )
• fewer adenoma and increased survival compared with ApcMin heterozygotes




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory