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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bptfem1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:6364856
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bptfem1Zfa/Bptfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6367576
cn2
 		Bptfem1Zfa/Bptfem1Zfa
Ehfem1Zfa/Ehfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6367579
cn3
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311735
cn4
 		Bptfem1Zfa/Bptfem1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311743


Genotype
MGI:6367576
cn1
Allelic
Composition		 Bptfem1Zfa/Bptfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:268724 )
• reduced intestinal stem cells with impaired organoid formation capacity




Genotype
MGI:6367579
cn2
Allelic
Composition		 Bptfem1Zfa/Bptfem1Zfa
Ehfem1Zfa/Ehfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Ehfem1Zfa mutation (0 available); any Ehf mutation (27 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:268724 )
• almost blocked organoid formation from intestinal stem cells

homeostasis/metabolism
abnormal response to radiation ( J:268724 )
• severely impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice




Genotype
MGI:7311735
cn3
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, overexpression of Zfp292 rescues ILC3 proliferation




Genotype
MGI:7311743
cn4
Allelic
Composition		 Bptfem1Zfa/Bptfem1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased susceptibility to bacterial infection ( J:259392 )
• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, and increased mortality compared with control mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to impaired proliferation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory