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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psma8em1Yuc
endonuclease-mediated mutation 1, Chao Yu
MGI:6364865
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psma8em1Yuc/Psma8em1Yuc C57BL/6-Psma8em1Yuc MGI:6364867


Genotype
MGI:6364867
hm1
Allelic
Composition		 Psma8em1Yuc/Psma8em1Yuc
Genetic
Background		 C57BL/6-Psma8em1Yuc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psma8em1Yuc mutation (0 available); any Psma8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:279342 )
N
• females are fertile
small testis ( J:279342 )
• dramatically smaller at P21 and P90
decreased testis weight ( J:279342 )
• weight is significantly lower from P21 to P90
• weight is 60% that of wild-type controls at P90
abnormal spermatogenesis ( J:279342 )
• diplonema spermatocytes and early-pachynema spermatocytes or pachynema spermatocytes are frequently seen in the same seminiferous tubules
abnormal spermatid morphology ( J:279342 )
• absence of spermatids in the seminiferous tubules
abnormal spermatocyte morphology ( J:279342 )
• absence of spermatocytes in the seminiferous tubule
arrest of male meiosis ( J:279342 )
• fail to progress through meiosis I
• progression to M phase is delayed and spermatocytes arrest at M phase
abnormal sperm physiology ( J:279342 )
• decrease in the level of 20S core proteasomes in pachynema spermatocytes
• increase in protein stability in spermatocytes

endocrine/exocrine glands
small testis ( J:279342 )
• dramatically smaller at P21 and P90
decreased testis weight ( J:279342 )
• weight is significantly lower from P21 to P90
• weight is 60% that of wild-type controls at P90

cellular
abnormal spermatid morphology ( J:279342 )
• absence of spermatids in the seminiferous tubules
abnormal spermatocyte morphology ( J:279342 )
• absence of spermatocytes in the seminiferous tubule
arrest of male meiosis ( J:279342 )
• fail to progress through meiosis I
• progression to M phase is delayed and spermatocytes arrest at M phase




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory