Analysis Tools
growth/size/body
homeostasis/metabolism
behavior/neurological
|
• distance moved in 6 seconds following the first and second footshock for conditioning of fear memory formation is higher than in wild-type mice
• however, the conditioning curve (total freezing and distance) in the conditioning session of the fear-conditioning test do not differ
• in the contextual test at 1 day after conditioning, mice show an increase in freezing response and a decrease in distance traveled
• enhancement of freezing responses is also seen 1 month after conditioning in the context testing
• sensitivity to nociceptive pain and overall freezing responses in the contextual and cued-fear conditioning tests are higher
|
|
• in the altered context chamber in the cued test (with tone), the freezing response is stronger 1 day after conditioning
• enhancement of freezing responses is also seen 1 month after conditioning in the cued testing with altered context
• sensitivity to nociceptive pain and overall freezing responses in the contextual and cued-fear conditioning tests are higher
|
|
• in the Barnes circular maze, mice spend less time around the correct hole at 1 month later, but not at 1 day after training, indicating impaired long-term memory
|
|
• mice exhibit reduced immobility in days 1 and 2 in the Porsolt forced swim test, indicating reduced depressive-like behavior
• in the tail suspension test, mice show modestly higher immobility in the latter half of the test
• however, no differences from wild-type mice are seen in the prepulse inhibition test
|
|
• in the light/dark transition test, mice show reduced distance traveled and time spent in the light chamber, suggesting increased anxiety-like behavior
• however, the first latency to enter the light chamber is shorter suggesting a reduction in anxiety-like behavior
• in the elevated plus maze, mice show a higher rate of entry into the open arms than wild-type mice, suggesting decreased anxiety-like behavior
|
|
• brake (as a percentage of stride and stance duration) and stance width of hind paws differ from wild-type mice in a gait analysis
• however, no differences in muscle strength and motor functions in the grip strength, wire hang or rotarod tests are seen
|
|
• vertical activity within 120 min is reduced in the open field
|
|
• in the open field test, mice show an increase in the total distance traveled
|
|
• stereotypic count within 10 min is reduced in the open field
|
|
• withdrawal threshold for mechanical stimuli in the von Frey test is lower than in wild-type mice
|
hyperalgesia
(
J:279657
)
|
• the higher freezing response is seen without the tone cue in the altered context chamber indicating a high sensitivity to nociceptive pain
|
|
• withdrawal latency from thermal stimulation in the hot-plate test is reduced
|
|
• in the social interaction test in the home cage, the number of contacts with another mouse during the dark period and activity level during the light period are lower, suggesting attenutated sociality and basal activity in the home cage
• however, no differences are seen in the novel environment and Crawleys social interaction tests
|
