All Phenotypes Mirc33<tm1.1Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi	C57BL/6N-Mirc33^tm1.1Wtsi	MGI:6367598
cx2	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi	C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi	MGI:6367622
cx3	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi Ppargc1a^tm1Brsp/Ppargc1a⁺	involves: 129S4/SvJae * C57BL/6N	MGI:6367623

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• premature death, with a median lifespan of 30 weeks compared to 123 weeks in controls

growth/size/body

decreased body weight ( J:267719 )

• mice develop body weight reduction after the 4th month of life

adipose tissue

decreased brown adipose tissue amount ( J:267719 )

• mice show a reduction in brown adipose tissue after the 4th month of life

decreased white adipose tissue amount ( J:267719 )

• mice show a reduction in white adipose tissue after the 4th month of life

decreased fat cell size ( J:267719 )

• mice exhibit smaller adipocytes

behavior/neurological

ataxia ( J:267719 )

• mice develop severe ataxia

hunched posture ( J:267719 )

• mice exhibit abnormal posture characterized by a hunched position

cardiovascular system

abnormal pulmonary artery morphology ( J:267719 )

• mice develop hypertrophy of small pulmonary arteries with thickening of the tunica media

abnormal aorta morphology ( J:267719 )

• aortas exhibit higher amount of elastic fibers indicating aortic fibrosis

abnormal aorta tunica adventitia morphology ( J:267719 )

• fibrotic accumulation in the tunica adventitia

increased aorta wall thickness ( J:267719 )

• medial thickening in the vessel wall of the aorta

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

hypertension ( J:267719 )

• mice develop systemic hypertension, showing higher levels of systemic blood pressure

cellular

increased mitochondrial DNA content ( J:267719 )

• increase in cardiac mitochondrial DNA

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller, with an accumulation of smaller rounded mitochondria in cardiomyocytes

increased mitochondrial number ( J:267719 )

• increase in the number of mitochondria in hearts

homeostasis/metabolism

decreased circulating creatinine level ( J:267719 )

• serum creatinine level is lower

• however, the kidneys do not show any morphological alteration

increased susceptibility to injury ( J:267719 )

• 3 month old mice administered angiotensin II develop more large fibrotic lesions than controls

• 3 month old mice show higher susceptibility to angiotensin II-induced cardiac heart failure, as 40% of mice die during treatment

renal/urinary system

distended urinary bladder ( J:267719 )

• severe bladder distension

abnormal urothelium morphology ( J:267719 )

• the growing pressure inside the bladder is accompanied by urothelium and muscular layer atrophy

ischuria ( J:267719 )

• urinary retention

reproductive system

infertility ( J:267719 )

skeleton

kyphosis ( J:267719 )

• mice develop thoracic kyphosis

vision/eye

ocular hypertension ( J:267719 )

blindness ( J:267719 )

• eye degeneration and blindness

Allelic Composition	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi
Genetic Background	C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc29^tm1.1Wtsi mutation (0 available); any Mirc29 mutation (1 available)
Mirc33^tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• life span is reduced to a median of 23 days

growth/size/body

decreased body weight ( J:267719 )

• mice show reduced body weight few days after birth

postnatal growth retardation ( J:267719 )

• striking growth retardation

cardiovascular system

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

homeostasis/metabolism

increased fasting circulating glucose level ( J:267719 )

• fasted mice exhibit hyperglycemia

decreased circulating glucose level ( J:267719 )

• reduction in serum glucose concentration in nonfasted mice

decreased circulating insulin level ( J:267719 )

Allelic Composition	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi Ppargc1a^tm1Brsp/Ppargc1a⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc33^tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)
Ppargc1a^tm1Brsp mutation (1 available); any Ppargc1a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• mice exhibit a life span extension compared with single Mirc33^tm1.1Wtsi homozygotes, with a median of 39.5 weeks compared to 30 weeks, but reduced survival compared to wild-type mice

cellular

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller

• however, cardiac mitochondrial DNA levels and mitochondrial numbers are restored to wild-type levels

cardiovascular system

cardiovascular system phenotype ( J:267719 )

N	• mice show a reduction in systemic blood pressure compared to single Mirc33^tm1.1Wtsi homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24