About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc29tm1.1Wtsi
targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI:6367595
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc29tm1.1Wtsi/Mirc29tm1.1Wtsi C57BL/6N-Mirc29tm1.1Wtsi MGI:6367620
cx2
 		Mirc29tm1.1Wtsi/Mirc29tm1.1Wtsi
Mirc33tm1.1Wtsi/Mirc33tm1.1Wtsi 		C57BL/6N-Mirc29tm1.1Wtsi Mirc33tm1.1Wtsi MGI:6367622


Genotype
MGI:6367620
hm1
Allelic
Composition		 Mirc29tm1.1Wtsi/Mirc29tm1.1Wtsi
Genetic
Background		 C57BL/6N-Mirc29tm1.1Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc29tm1.1Wtsi mutation (0 available); any Mirc29 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:267719 )
• slight decrease in body weight
• however, mice develop normally without any obvious alterations

renal/urinary system
ischuria ( J:267719 )
• old mice develop urinary retention with incomplete penetrance

cardiovascular system
cardiovascular system phenotype ( J:267719 )
N
• no fibrotic accumulation in the coronary arteries is seen




Genotype
MGI:6367622
cx2
Allelic
Composition		 Mirc29tm1.1Wtsi/Mirc29tm1.1Wtsi
Mirc33tm1.1Wtsi/Mirc33tm1.1Wtsi
Genetic
Background		 C57BL/6N-Mirc29tm1.1Wtsi Mirc33tm1.1Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc29tm1.1Wtsi mutation (0 available); any Mirc29 mutation (1 available)
Mirc33tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:267719 )
• life span is reduced to a median of 23 days

growth/size/body
decreased body weight ( J:267719 )
• mice show reduced body weight few days after birth
postnatal growth retardation ( J:267719 )
• striking growth retardation

cardiovascular system
abnormal heart morphology ( J:267719 )
• necrotic areas with collagen accumulation are seen in hearts

homeostasis/metabolism
increased fasting circulating glucose level ( J:267719 )
• fasted mice exhibit hyperglycemia
decreased circulating glucose level ( J:267719 )
• reduction in serum glucose concentration in nonfasted mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory