Phenotypes associated with this allele

• Allele Symbol: Ppp1r3g^tm1Nju
• Allele Name: targeted mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6367634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r3g^tm1Nju/Ppp1r3g^tm1Nju	B6.129-Ppp1r3g^tm1Nju	MGI:6367636

Genotype
MGI:6367636

hm1

• Allelic Composition: Ppp1r3g^tm1Nju/Ppp1r3g^tm1Nju
• Genetic Background: B6.129-Ppp1r3g^tm1Nju

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:249135 )

♂ • when fed a high-fat diet for 20 weeks, males gain significantly less weight than wild-type controls at most time points examined, despite an increase in food consumption

♂ • however, no differences in weight gain are observed on a normal chow diet

increased carbon dioxide production ( J:249135 )

♂ • on a high-fat diet, CO₂ production is significantly higher than that in wild-type controls

increased oxygen consumption ( J:249135 )

♂ • on a high-fat diet, O₂ consumption is significantly higher than that in wild-type controls

abnormal glucose homeostasis ( J:249135 )

♂ • in a food tolerance test (where mice are fasted overnight and refed with normal chow), postprandial glucose clearance is significantly increased, as blood glucose levels after feeding are significantly lower than those in wild-type controls

♂ • however, glucose tolerance is not altered under a high-fat diet

decreased adipose tissue glycogen level ( J:249135 )

♂ • on a high-fat diet, glycogen concentration in epididymal fat pad (WAT) is reduced by 30% relative to that in wild-type controls

decreased liver glycogen level ( J:249135 )

♂ • on a high-fat diet, liver glycogen level is significantly lower than that in wild-type controls (10.9 mg/g versus 19.1 mg/g, respectively)

♂ • however, liver weight is normal under a high-fat diet

increased insulin sensitivity ( J:249135 )

♂ • in an insulin tolerance test (ITT), males fed a high-fat diet show significantly lower blood glucose levels than wild-type controls before and after insulin administration

increased basal metabolism ( J:249135 )

♂ • on a high-fat diet, the metabolic rate of males is significantly higher than that in wild-type controls, as measured by O₂ consumption and CO₂ production

♂ • however, respiratory exchange ratio (RER) is normal indicating that the energy source consumed is not altered

growth/size/body

decreased body fat mass ( J:249135 )

♂ • on a high-fat diet, the % of fat mass is significantly lower than that in wild-type controls (16.7% versus 27.1%, respectively)

increased lean body mass ( J:249135 )

♂ • on a high-fat diet, the % of lean mass is significantly higher than that in wild-type controls

decreased susceptibility to diet-induced obesity ( J:249135 )

♂ • when fed a high-fat diet for 20 weeks, males gain significantly less weight than wild-type controls at most time points examined, despite an increase in food consumption

♂ • however, no differences in weight gain are observed on a normal chow diet

behavior/neurological

behavior/neurological phenotype ( J:249135 )

♂N • on a high-fat diet, males show normal physical (voluntary) activity through a 12-hr light/dark cycle

increased food intake ( J:249135 )

♂ • on a high-fat diet, daily food intake per g of body weight is significantly higher than that in wild-type controls

♂ • however, no differences in food intake are observed on a normal chow diet

liver/biliary system

decreased liver glycogen level ( J:249135 )

♂ • on a high-fat diet, liver glycogen level is significantly lower than that in wild-type controls (10.9 mg/g versus 19.1 mg/g, respectively)

♂ • however, liver weight is normal under a high-fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:249135 )

♂ • on a high-fat diet, liver triglyceride level is only slightly lower while lipid accumulation in the liver is markedly decreased relative to that in wild-type controls as shown by Oil Red O staining

adipose tissue

decreased adipose tissue glycogen level ( J:249135 )

♂ • on a high-fat diet, glycogen concentration in epididymal fat pad (WAT) is reduced by 30% relative to that in wild-type controls

decreased body fat mass ( J:249135 )

♂ • on a high-fat diet, the % of fat mass is significantly lower than that in wild-type controls (16.7% versus 27.1%, respectively)

decreased epididymal fat pad weight ( J:249135 )

♂ • on a high-fat diet, the epididymal WAT to body weight ratio is significantly lower than that in wild-type controls (3.31% versus 4.71%, respectively)