Phenotypes associated with this allele

• Allele Symbol: Cct7^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6367820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cct7^em1(IMPC)J/Cct7^em1(IMPC)J	C57BL/6NJ-Cct7^em1(IMPC)J/Mmjax	MGI:6696678
ht2	Cct7^em1(IMPC)J/Cct7^+	C57BL/6NJ-Cct7^em1(IMPC)J/Mmjax	MGI:7266983

Genotype
MGI:6696678

hm1

• Allelic Composition: Cct7^em1(IMPC)J/Cct7^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Cct7^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Cct7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cct7^em1(IMPC)J/Cct7^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although early blastocysts are present in nearly normal Mendelian ratios at E3.5 (21% versus expected 25%), no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:7266983

ht2

• Allelic Composition: Cct7^em1(IMPC)J/Cct7⁺
• Genetic Background: C57BL/6NJ-Cct7^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Cct7

behavior/neurological

decreased vertical activity ( J:211773 )

IMPC - JAX