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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ttkem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6367822
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ttkem1(IMPC)J/Ttkem1(IMPC)J C57BL/6NJ-Ttkem1(IMPC)J/Mmjax MGI:6493177
ht2
 		Ttkem1(IMPC)J/Ttk+ C57BL/6NJ-Ttkem1(IMPC)J/Mmjax MGI:7768449


Genotype
MGI:6493177
hm1
Allelic
Composition		 Ttkem1(IMPC)J/Ttkem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Ttkem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttkem1(IMPC)J mutation (2 available); any Ttk mutation (53 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ttkem1(IMPC)J/Ttkem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form outgrowths with apparent trophectoderm and primitive endoderm cells, but small inner cell mass.

embryo
abnormal inner cell mass morphology ( J:279207 )
• in vitro outgrowth assays show apparent trophectoderm (TE) and primitive endoderm (PrE) cells but a small ICM after 3 days in culture

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• blastocysts-like embryos are recovered at E3.5 (12% versus expected 25%, n=43); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7768449
ht2
Allelic
Composition		 Ttkem1(IMPC)J/Ttk+
Genetic
Background		 C57BL/6NJ-Ttkem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttkem1(IMPC)J mutation (2 available); any Ttk mutation (53 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory