Phenotypes associated with this allele

• Allele Symbol: Smarcd3^tm1Jddl
• Allele Name: targeted mutation 1, Jiandie D Lin
• Allele ID: MGI:6367829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myl1^tm1(cre)Sjb/Myl1^+ Smarcd3^tm1Jddl/Smarcd3^tm1Jddl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6367830

Genotype
MGI:6367830

cn1

• Allelic Composition: Myl1^tm1(cre)Sjb/Myl1⁺; Smarcd3^tm1Jddl/Smarcd3^tm1Jddl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:256788 )

• mice exhibit elevated postprandial blood glucose after refeeding

• streptozotocin-treated mice have higher blood glucose levels than controls despite similarly low levels of plasma insulin

• high fat diet fed and streptozotocin-treated mice show an attenuated effect of the sufonylurea drug glibenclamide on blood glucose levels

impaired glucose tolerance ( J:256788 )

• glucose tolerance test indicates that high fat diet-fed mice are more glucose intolerant than controls

• streptozotocin-treated mice are more glucose-intolerant and develop more severe postprandial hyperglycemia following refeeding

• however, plasma insulin concentrations during glucose tolerance test are similar to controls

insulin resistance ( J:256788 )

• insulin tolerance test indicates that high fat diet-fed mice are more insulin resistant than controls

• streptozotocin-treated mice are more insulin-resistant

muscle

abnormal muscle physiology ( J:256788 )

• glucose-induced lactate production in plantaris, EDL, and soleus muscles cultured ex vivo is impaired

• however, muscle mass, endurance exercise capacity and muscle development are unaffected

growth/size/body

growth/size/body region phenotype ( J:256788 )

N • chow-fed mice exhibit normal body weight and muscle mass