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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sptbem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6367831
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sptbem1(IMPC)J/Sptbem1(IMPC)J C57BL/6NJ-Sptbem1(IMPC)J/Mmjax MGI:7317073
ht2
 		Sptbem1(IMPC)J/Sptb+ C57BL/6NJ-Sptbem1(IMPC)J/Mmjax MGI:7267095


Genotype
MGI:7317073
hm1
Allelic
Composition		 Sptbem1(IMPC)J/Sptbem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Sptbem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbem1(IMPC)J mutation (2 available); any Sptb mutation (85 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sptbem1(IMPC)J/Sptbem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and are dead after 72hr in vitro, never forming outgrowths.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture
abnormal morula morphology ( J:279207 )
• embryos recovered at E3.5 appear as dying morulae

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• homozygous embryos are recovered at E3.5 (10% versus expected 25%, n=42) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro, embryos fail to hatch and are dead after 3 days in culture, never forming outgrowths




Genotype
MGI:7267095
ht2
Allelic
Composition		 Sptbem1(IMPC)J/Sptb+
Genetic
Background		 C57BL/6NJ-Sptbem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbem1(IMPC)J mutation (2 available); any Sptb mutation (85 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory