Phenotypes associated with this allele

• Allele Symbol: Wdr91^tm2Bcgen
• Allele Name: targeted mutation 2, Biocytogen LLC
• Allele ID: MGI:6368014
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wdr91^tm2Bcgen/Wdr91^tm2Bcgen Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6368206

Genotype
MGI:6368206

cn1

• Allelic Composition: Wdr91^tm2Bcgen/Wdr91^tm2Bcgen; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:247712 )

• beginning at P21 with all mice dying by 28 weeks

nervous system

increased neuron apoptosis ( J:247712 )

• at P21

abnormal neuron differentiation ( J:247712 )

• with increased enlarged intermediate endosomes

decreased brain size ( J:247712 )

• at P21, but no P10

decreased brain weight ( J:247712 )

• progressive at P10 and P21

• however, weight is normal at P0

thin cerebral cortex ( J:247712 )

abnormal neurite morphology ( J:247712 )

• reduced length and complexity

abnormal dendrite morphology ( J:247712 )

• reduced length and complexity of granular neurons at P21

• reduced branching in both the hippocampal dentate gyrus and the cortex neurons

• however, dendrite length is normal at P10

growth/size/body

postnatal growth retardation ( J:247712 )

• progressive at P21

• however, growth is normal at P0 and P10

cellular

increased neuron apoptosis ( J:247712 )

• at P21

abnormal neuron differentiation ( J:247712 )

• with increased enlarged intermediate endosomes