All Phenotypes Porcn<tm1.2Lcm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Porcn^tm1.2Lcm
targeted mutation 1.2, Lewis Murtaugh
MGI:6368150

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Porcn^tm1.2Lcm/Porcn^tm1.2Lcm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * DBA/2	MGI:6368188
ht2	Porcn^tm1.1Lcm/Porcn^tm1.2Lcm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	MGI:6368182
cn3	Porcn^tm1.1Lcm/Porcn^tm1.2Lcm Tg(Six3-cre)69Frty/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * DBA/2	MGI:6368181

Allelic Composition	Porcn^tm1.2Lcm/Porcn^tm1.2Lcm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.2Lcm mutation (0 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:218165 )

• limb atrophy

forelimb oligodactyly ( J:218165 )

• absence of digits in the forelimb

syndactyly ( J:218165 )

short tail ( J:218165 )

curly tail ( J:218165 )

craniofacial

abnormal craniofacial morphology ( J:218165 )

• in some mice

vision/eye

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

failure of eyelid fusion ( J:218165 )

• open eyelids in some mice between E16.5 and E18.0 in all mice

coloboma ( J:218165 )

• at E13.5

nervous system

abnormal midbrain-hindbrain boundary morphology ( J:218165 )

• in some mice

embryo

caudal body truncation ( J:218165 )

pigmentation

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:218165

Allelic Composition	Porcn^tm1.1Lcm/Porcn^tm1.2Lcm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Lcm mutation (0 available); any Porcn mutation (18 available)
Porcn^tm1.2Lcm mutation (0 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

failure of eyelid fusion ( J:218165 )

• open eyelids in some mice between E16.5 and E18.0 in some mice

coloboma ( J:218165 )

• in some mice

nervous system

abnormal midbrain-hindbrain boundary morphology ( J:218165 )

• in some mice

craniofacial

abnormal craniofacial morphology ( J:218165 )

• in some mice

pigmentation

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:218165

Allelic Composition	Porcn^tm1.1Lcm/Porcn^tm1.2Lcm Tg(Six3-cre)69Frty/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:218165 )

• in some mice

vision/eye

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

failure of eyelid fusion ( J:218165 )

• open eyelids in some mice between E16.5 and E18.0 in all mice

coloboma ( J:218165 )

• at E13.5

growth/size/body

failure of ventral body wall closure ( J:218165 )

nervous system

abnormal midbrain-hindbrain boundary morphology ( J:218165 )

• in some mice

pigmentation

abnormal retina pigmentation ( J:218165 )

• severe to mild loss of pigment in the dorsal retina pigmented epithelium

integument

skin hypoplasia ( J:218165 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:218165

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24