Analysis Tools
cardiovascular system
cellular
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• decrease in the number of round of spermatids
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• decrease in the number of round of spermatids
• however, no differences in testes weight, diameter of seminiferous tubules, or number of primary spermatocytes are seen and mice are fertile
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• MEFs subjected to stress (SNAP, gamma-irradiation, UV irradiation, Adriamycin, hydrogen peroxide, and cytokines) show increased apoptosis
• however, mice show no differences from wild-type mice in response to lipopolysaccharide-induced endotoxic shock
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• MEFs show increased apoptosis when subjected to Adriamycin treatment
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• MEFs show increased apoptosis when subjected to gamma-irradiation
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• MEFs show increased apoptosis when subjected to hydrogen peroxide treatment
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• MEFs show increased apoptosis when subjected to UV irradiation
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• MEFs exhibit a higher fraction of sub-G1 cells and have larger numbers of apoptotic cells indicating increased cell death
• however, MEFs have normal growth and response to the nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP)
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hematopoietic system
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• mice show a 12% increase in the number of colony forming cell-8d cells in the spleen an a 45.5% decrease in Sca1+ cells in the bone marrow
• however, no differences in the blood cell profile in peripheral blood, spleen, or bone marrow, in the number of colony forming cell-8d and colony forming-12d cells in the bone marrow, or in the number of colony forming cell-12d colonies
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reproductive system
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• decrease in the number of round of spermatids
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• decrease in the number of round of spermatids
• however, no differences in testes weight, diameter of seminiferous tubules, or number of primary spermatocytes are seen and mice are fertile
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growth/size/body
