Phenotypes associated with this allele

• Allele Symbol: Myrip^tm1Tiz
• Allele Name: targeted mutation 1, Tetsuro Izumi
• Allele ID: MGI:6368190
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myrip^tm1Tiz/Myrip^tm1Tiz	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:6368191

Genotype
MGI:6368191

hm1

• Allelic Composition: Myrip^tm1Tiz/Myrip^tm1Tiz
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:258210 )

♂ • mice show slightly reduced body weight

homeostasis/metabolism

decreased insulin secretion ( J:258210 )

♂ • pancreatic islets show decreased insulin secretion in response to glucose, potassium, or forskolin with gluocose, but not in response to phorbol-12-myristate-13-acetate with glucose

impaired glucose tolerance ( J:258210 )

♂ • mice exhibit higher blood glucose levels after a glucose load indicating glucose intolerance

♂ • however, insulin sensitivity is not altered

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:258210 )

♂ • insulin granules are diffusely distributed in the perinuclear cytoplasm in islets instead of being polarized close to the cell edges as in wild-type islets

abnormal pancreatic beta cell morphology ( J:258210 )

♂ • beta-cells have a lower number of granules that close to the plasma membrane

♂ • however, they still exhibit granules directly attached to the plasma membrane

decreased insulin secretion ( J:258210 )

♂ • pancreatic islets show decreased insulin secretion in response to glucose, potassium, or forskolin with gluocose, but not in response to phorbol-12-myristate-13-acetate with glucose