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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpat2tm1.1Nkn
targeted mutation 1.1, Toru Nakano
MGI:6368203
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpat2tm1.1Nkn/Gpat2tm1.1Nkn involves: 129S2/SvPas * C57BL/6NSlc MGI:6368204


Genotype
MGI:6368204
hm1
Allelic
Composition		 Gpat2tm1.1Nkn/Gpat2tm1.1Nkn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpat2tm1.1Nkn mutation (0 available); any Gpat2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:277128 )
N
• females are fertile
abnormal male germ cell morphology ( J:277128 )
• intermitochondrial cement is absent from E16.5 prospermatogonia
azoospermia ( J:277128 )
• absence of sperm in the cauda epididymis
abnormal spermatocyte morphology ( J:277128 )
• pachytene spermatocytes with thick synaptonemal complexes are rarely seen
increased male germ cell apoptosis ( J:277128 )
• increase in apoptosis is seen by 3 days of age
abnormal DNA methylation during gametogenesis ( J:277128 )
• DNA methylation of retrotransposon genes is completely impaired in male germ cells
decreased testis weight ( J:277128 )
• ratio of testes weight to body weight is significantly reduced compared to controls in mice over 2 weeks of age

endocrine/exocrine glands
decreased testis weight ( J:277128 )
• ratio of testes weight to body weight is significantly reduced compared to controls in mice over 2 weeks of age

cellular
abnormal male germ cell morphology ( J:277128 )
• intermitochondrial cement is absent from E16.5 prospermatogonia
azoospermia ( J:277128 )
• absence of sperm in the cauda epididymis
abnormal spermatocyte morphology ( J:277128 )
• pachytene spermatocytes with thick synaptonemal complexes are rarely seen
increased male germ cell apoptosis ( J:277128 )
• increase in apoptosis is seen by 3 days of age
abnormal DNA methylation during gametogenesis ( J:277128 )
• DNA methylation of retrotransposon genes is completely impaired in male germ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory