All Phenotypes Rr172<em1Kmm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr172^em1Kmm
endonuclease-mediated mutation 1, Kenneth Murphy
MGI:6368518

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rr172^em1Kmm/Rr172^em1Kmm Rr253^em6Kmm/Rr253^em6Kmm	C57BL/6J-Rr253^em6Kmm Rr172^em1Kmm	MGI:7448526

Allelic Composition	Rr172^em1Kmm/Rr172^em1Kmm Rr253^em6Kmm/Rr253^em6Kmm
Genetic Background	C57BL/6J-Rr253^em6Kmm Rr172^em1Kmm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr172^em1Kmm mutation (1 available); any Rr172 mutation (0 available)
Rr253^em6Kmm mutation (1 available); any Rr253 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:334296 )

N	• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus) • normal splenic cDC2 numbers

decreased granulocyte monocyte progenitor cell number ( J:334296 )

• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow

decreased dendritic cell number ( J:334296 )

• bone marrow pre-cDC2s virtually absent

• splenic cDC1s virtually absent

increased dendritic cell number ( J:334296 )

• increase of bone marrow pre-cDC1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow

immune system

immune system phenotype ( J:334296 )

N	• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus) • normal splenic cDC2 numbers

decreased dendritic cell number ( J:334296 )

• bone marrow pre-cDC2s virtually absent

• splenic cDC1s virtually absent

increased dendritic cell number ( J:334296 )

• increase of bone marrow pre-cDC1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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