Phenotypes associated with this allele

• Allele Symbol: Rr172^em1Kmm
• Allele Name: endonuclease-mediated mutation 1, Kenneth Murphy
• Allele ID: MGI:6368518
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rr172^em1Kmm/Rr172^em1Kmm Rr253^em6Kmm/Rr253^em6Kmm	C57BL/6J-Rr253^em6Kmm Rr172^em1Kmm	MGI:7448526

Genotype
MGI:7448526

cx1

• Allelic Composition: Rr172^em1Kmm/Rr172^em1Kmm; Rr253^em6Kmm/Rr253^em6Kmm
• Genetic Background: C57BL/6J-Rr253^em6Kmm Rr172^em1Kmm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:334296 )

N • normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)

N • normal splenic cDC2 numbers

decreased granulocyte monocyte progenitor cell number ( J:334296 )

• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow

decreased dendritic cell number ( J:334296 )

• bone marrow pre-cDC2s virtually absent

• splenic cDC1s virtually absent

increased dendritic cell number ( J:334296 )

• increase of bone marrow pre-cDC1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow

immune system

immune system phenotype ( J:334296 )

N • normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)

N • normal splenic cDC2 numbers

decreased dendritic cell number ( J:334296 )

• bone marrow pre-cDC2s virtually absent

• splenic cDC1s virtually absent

increased dendritic cell number ( J:334296 )

• increase of bone marrow pre-cDC1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow