Phenotypes associated with this allele

• Allele Symbol: Snx6^tm1.1Nju
• Allele Name: targeted mutation 1.1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6368549
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Snx6^tm1.1Nju/Snx6^tm1.1Nju Tg(Nes-cre)1Kln/0	involves: C57BL/6NTac * SJL	MGI:6368613

Genotype
MGI:6368613

cn1

• Allelic Composition: Snx6^tm1.1Nju/Snx6^tm1.1Nju; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:240866 )

N • mice exhibit normal structure of the cortex, hippocampus and cerebellum

N • mice exhibit normal NMDAR-mediated eEPSCs and pair-pulse ratio of AMPAR eEPSCs

decreased dendritic spine density ( J:240866 )

• in distal apical dendrites of hippocampal CA1 pyramidal neurons

abnormal asymmetric synapse morphology ( J:240866 )

• decreased asymmetric/excitatory synapses in the CA1, but not in the CA3 region

abnormal excitatory synapse morphology ( J:240866 )

• decreased asymmetric/excitatory synapses in the CA1, but not in the CA3 region

reduced AMPA-mediated synaptic currents ( J:240866 )

• reduced evoked excitatory postsynaptic current

behavior/neurological

behavior/neurological phenotype ( J:240866 )

N • mice exhibit normal sociability and social novelty and performance in elevated plus maze, tail suspension, forced swimming, and Y maze and shuttle box tests

impaired spatial learning ( J:240866 )

• in a Morris water maze test

abnormal spatial working memory ( J:240866 )

• severely impaired in a Morris water maze test