All Phenotypes Bcap31<tm1.1Bwang> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6714084
cn2	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Tg(Lck-cre)548Jxm/0	involves: C57BL/6 * CBA	MGI:6719029

Allelic Composition	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcap31^tm1.1Bwang mutation (0 available); any Bcap31 mutation (8 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

increased interleukin-1 beta secretion ( J:292505 )

• increased Il1b mRNA levels in the hippocampus after i.c.v. LPS administration

• increased IL-1beta protein levels in primary microglial cells after LPS administration for 24 h

increased tumor necrosis factor secretion ( J:292505 )

• increased Tnf mRNA levels in the hippocampus after i.c.v. LPS administration

• increased TNF protein levels in primary microglial cells after LPS administration for 24 h

increased inflammatory response ( J:292505 )

• increased mRNA expression of proinflammatory factors (Tnf, Il1b, Nos2 and Ptgs2) in the hippocampus after i.c.v. LPS administration

nervous system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

decreased neuron number ( J:292505 )

• decreased number of NeuN-labeled intact neurons in the hippocampal CA1 and dentate gurus (DG) areas after i.c.v. LPS administration

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:292505 )

• increased Nos2 (nitric oxide synthase 2, inducible; aka iNOS) and Ptgs2 (prostaglandin-endoperoxide synthase 2; aka cyclooxygenase-2, Cox2) mRNA levels in the hippocampus following i.c.v. LPS administration

behavior/neurological

behavior/neurological phenotype ( J:292505 )

N	• no alterations in spontaneous locomotor activity (total moving distance) in the open field test 7 days after i.c.v. LPS administration at 2 months of age

abnormal spatial reference memory ( J:292505 )

• mice exhibit severe deficits in spatial memory formation after i.c.v. LPS administration

• in the Morris water maze test, the escape latency on training day 3, 4 and 5 is longer in LPS-treated mice relative to that in LPS-treated controls; in the probe test, LPS-treated mice show a reduced number of platform-site crossings, travel a shorter distance and spend less time in the target quadrant than LPS-treated controls

• in the Y-maze test, LPS-treated mice show a reduced number of alterations but no change in the total number of arm entries relative to LPS-treated controls

hematopoietic system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )

• decreased % of naive (CD44^lowCD62L^hi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

increased effector memory T-helper cell number ( J:274469 )

• increased % of effector/memory T cells (CD44^hiCD62L^lo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

decreased single-positive T cell number ( J:274469 )

• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

• decreased percentage of CD4+ and CD8+ T cells in peripheral blood

• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal

abnormal T cell activation ( J:274469 )

• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased interferon-gamma secretion ( J:274469 )

• marked reduction in IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level

decreased interleukin-2 secretion ( J:274469 )

• marked reduction in IL-2 production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level

hematopoietic system

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )

• decreased % of naive (CD44^lowCD62L^hi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

increased effector memory T-helper cell number ( J:274469 )

• increased % of effector/memory T cells (CD44^hiCD62L^lo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

decreased single-positive T cell number ( J:274469 )

• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

• decreased percentage of CD4+ and CD8+ T cells in peripheral blood

• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal

abnormal T cell activation ( J:274469 )

• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

cellular

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

endocrine/exocrine glands

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

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