Phenotypes associated with this allele

• Allele Symbol: Cyp4x1^tm1.1Beld
• Allele Name: targeted mutation 1.1, David Bell
• Allele ID: MGI:6368621
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp4x1^tm1.1Beld/Cyp4x1^tm1.1Beld	involves: C57BL/6	MGI:6368622

Genotype
MGI:6368622

hm1

• Allelic Composition: Cyp4x1^tm1.1Beld/Cyp4x1^tm1.1Beld
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:254435 )

• on a normal chow diet, body weight is significantly greater than that in controls after 14 weeks of age in males and after 11 weeks of age in females

• however, group mean food intake (measured in home cage) is not significantly different from that in controls

increased susceptibility to weight gain ( J:254435 )

• on a normal chow diet, both male and female mice gain significantly more body weight than controls; increase in weight gain is late onset, more pronounced in females than in males, and continues up to 19 weeks of age

• however, total food intake per 24h, meal frequency and meal size are normal

increased susceptibility to diet-induced obesity ( J:254435 )

♀ • on a high fat diet, female but not male mice gain weight at a significantly greater rate than controls; increase in body weight is noted as early as 8 weeks of age (i.e. 4 weeks after initial exposure to the high fat diet) and continues up to 15 weeks of age

adipose tissue

increased abdominal adipose tissue amount ( J:254435 )

♂ • on a normal chow diet, males show significantly greater intra-abdominal fat deposits, apparently due to hypertrophy of adipocytes

increased white fat cell size ( J:254435 )

♂ • on a normal chow diet, mean adipocyte diameter within epididymal fat pads is significantly greater than that in controls

increased epididymal fat pad weight ( J:254435 )

♂ • on a normal chow diet, epididymal fat pad weight is significantly greater than that in controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:254435 )

N • at 20 weeks of age, both male and female mice show normal glucose homeostasis in glucose and insulin tolerance tests

increased susceptibility to diet-induced obesity ( J:254435 )

♀ • on a high fat diet, female but not male mice gain weight at a significantly greater rate than controls; increase in body weight is noted as early as 8 weeks of age (i.e. 4 weeks after initial exposure to the high fat diet) and continues up to 15 weeks of age

decreased oxygen consumption ( J:254435 )

• on a high fat diet, oxygen consumption is significantly decreased in both males and females during both the light and dark phases

decreased respiratory quotient ( J:254435 )

♂ • on a normal chow diet, males but not females show a significantly lower respiratory exchange ratio than controls

behavior/neurological

decreased locomotor activity ( J:254435 )

♀ • on a high fat diet, females but not males show significantly decreased locomotor activity levels in both the light and dark periods