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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Armc2em1Pfr
endonuclease-mediated mutation 1, Pierre Ray
MGI:6368816
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Armc2em1Pfr/Armc2em1Pfr Not Specified MGI:6369630


Genotype
MGI:6369630
hm1
Allelic
Composition		 Armc2em1Pfr/Armc2em1Pfr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc2em1Pfr mutation (0 available); any Armc2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:279937 )
N
• females are fully fertile and give litters of normal size
oligozoospermia ( J:279937 )
• concentrations of sperm from the cauda epididymis are significantly lower than those in wild-type males
abnormal sperm flagellum morphology ( J:279937 )
• almost 100% of epididymal spermatozoa exhibit severe flagellar defects, including short, coiled, absent, and/or flagella of irregular caliber
• however, testis weight is normal and sperm heads display an overall typical hooked shape
absent sperm axonemal central pair ( J:279937 )
• immunostaining revealed that SPEF2 (a marker of the central-pair complex (CPC) of microtubules) is totally absent, indicating a 9 + 0 axoneme lacking a CPC
immotile sperm ( J:279937 )
• sperm extracted from the cauda epididymis show complete loss of total motility
male infertility ( J:279937 )
• males exhibited complete infertility when mated with wild-type females

cellular
oligozoospermia ( J:279937 )
• concentrations of sperm from the cauda epididymis are significantly lower than those in wild-type males
abnormal sperm flagellum morphology ( J:279937 )
• almost 100% of epididymal spermatozoa exhibit severe flagellar defects, including short, coiled, absent, and/or flagella of irregular caliber
• however, testis weight is normal and sperm heads display an overall typical hooked shape
absent sperm axonemal central pair ( J:279937 )
• immunostaining revealed that SPEF2 (a marker of the central-pair complex (CPC) of microtubules) is totally absent, indicating a 9 + 0 axoneme lacking a CPC
immotile sperm ( J:279937 )
• sperm extracted from the cauda epididymis show complete loss of total motility

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
male infertility DOID:12336 J:279937




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory