Phenotypes associated with this allele

• Allele Symbol: Tbx6^em1Fzh
• Allele Name: endonuclease-mediated mutation 1, Feng Zhang
• Allele ID: MGI:6368858
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx6^em1Fzh/Tbx6^em1Fzh	FVB/NJ-Tbx6^em1Fzh	MGI:6441992
ht2	Tbx6^em1Fzh/Tbx6^+	FVB/NJ-Tbx6^em1Fzh	MGI:6441993
ht3	Tbx6^em1Fzh/Tbx6^em2Fzh	FVB/NJ-Tbx6^em1Fzh Tbx6^em2Fzh	MGI:6441997

Genotype
MGI:6441992

hm1

• Allelic Composition: Tbx6^em1Fzh/Tbx6^em1Fzh
• Genetic Background: FVB/NJ-Tbx6^em1Fzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:271649 )

• no homozygous mice are obtained

Genotype
MGI:6441993

ht2

• Allelic Composition: Tbx6^em1Fzh/Tbx6⁺
• Genetic Background: FVB/NJ-Tbx6^em1Fzh

skeleton

skeleton phenotype ( J:271649 )

N • mice show no evidence of congenital vertebral malformations

Genotype
MGI:6441997

ht3

• Allelic Composition: Tbx6^em1Fzh/Tbx6^em2Fzh
• Genetic Background: FVB/NJ-Tbx6^em1Fzh Tbx6^em2Fzh

skeleton

rib fusion ( J:271649 )

abnormal vertebrae development ( J:271649 )

• 93% of embryos and 100% of adult mice (35-445 days) exhibit congenital vertebral malformations

vertebral fusion ( J:271649 )