Phenotypes associated with this allele

• Allele Symbol: Tafa4^tm1.1Azmo
• Allele Name: targeted mutation 1.1, Aziz Moqrich
• Allele ID: MGI:6368862
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tafa4^tm1.1Azmo/Tafa4^tm1.1Azmo	involves: 129S2/SvPas * C57BL/6J	MGI:6368879

Genotype
MGI:6368879

hm1

• Allelic Composition: Tafa4^tm1.1Azmo/Tafa4^tm1.1Azmo
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased chemical nociceptive threshold ( J:203770 )

• in a Carrageenan model

abnormal mechanical nociception ( J:203770 )

• prolonged pain hypersensitivity in a Carrageenan model and a chronic constriction of the sciatic nerve model

abnormal nociception after inflammation ( J:203770 )

• in a Carrageenan or formalin model, mice exhibit increased chemical and mechanical nociception compared with wild-type mice

nervous system

nervous system phenotype ( J:203770 )

N • mice exhibit normal neuron numbers and action potential properties

abnormal nervous system electrophysiology ( J:203770 )

• increased action potentials in lamina IIi neurons injected with depolarizing current pulses of increased amplitudes with increased discharge frequency at the beginning of the current pulse

• lamina IIi neurons stimulated with a voltage ramp protocol fail to exhibit an outward current with slow desensitization at the end of the rising voltage ramp compared with wild-type neurons

abnormal action potential ( J:203770 )

• higher rebound action potential after injection of hyperpolarizing current pulses