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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx6em2Fzh
endonuclease-mediated mutation 2, Feng Zhang
MGI:6368863
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx6em2Fzh/Tbx6em2Fzh FVB/NJ-Tbx6em2Fzh MGI:6441995
ht2
 		Tbx6em1Fzh/Tbx6em2Fzh FVB/NJ-Tbx6em1Fzh Tbx6em2Fzh MGI:6441997


Genotype
MGI:6441995
hm1
Allelic
Composition		 Tbx6em2Fzh/Tbx6em2Fzh
Genetic
Background		 FVB/NJ-Tbx6em2Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6em2Fzh mutation (0 available); any Tbx6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:271649 )
N
• mice show no evidence of congenital vertebral malformations




Genotype
MGI:6441997
ht2
Allelic
Composition		 Tbx6em1Fzh/Tbx6em2Fzh
Genetic
Background		 FVB/NJ-Tbx6em1Fzh Tbx6em2Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6em1Fzh mutation (0 available); any Tbx6 mutation (17 available)
Tbx6em2Fzh mutation (0 available); any Tbx6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae development ( J:271649 )
• 93% of embryos and 100% of adult mice (35-445 days) exhibit congenital vertebral malformations




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory