Phenotypes associated with this allele

• Allele Symbol: Ccdc51^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:6368872
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc51^tm1.1Geno/Ccdc51^tm1.1Geno	involves: C57BL/6N	MGI:6369026

Genotype
MGI:6369026

hm1

• Allelic Composition: Ccdc51^tm1.1Geno/Ccdc51^tm1.1Geno
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:279978 )

• following ischemia-reperfusion, hearts of untreated mice exhibit a slightly higher % of lactate dehydrogenase (LDH) release than those of wild-type controls, indicating more heart injury

• hearts are resistant to diazoxide-induced cardioprotection from reperfusion damage, showing a significantly higher % of LDH release and infarct size than similarly treated wild-type hearts

cellular

abnormal mitochondrial physiology ( J:279978 )

• whereas energized mitochondria from wild-type livers show ATP- and diazoxide-sensitive K⁺ uptake, neither ATP nor diazoxide are able to alter K⁺ fluxes in mutant mitochondria, indicating lack of mitochondrial K_ATP activity

homeostasis/metabolism

increased response of heart to induced stress ( J:279978 )

• following ischemia-reperfusion, hearts of untreated mice exhibit a slightly higher % of lactate dehydrogenase (LDH) release than those of wild-type controls, indicating more heart injury

• hearts are resistant to diazoxide-induced cardioprotection from reperfusion damage, showing a significantly higher % of LDH release and infarct size than similarly treated wild-type hearts